Women with endometriosis at greater associated risk of heart attack and stroke, research finds

According to analysis introduced at ESC Congress 2024, girls with endometriosis have a 20% better threat of serious cardiac outcomes in contrast with girls with out endometriosis.

“For many years, heart problems (CVD) has been considered a person’s illness and threat components have been thought-about from the male perspective, for instance, together with erectile dysfunction in pointers on CVD threat evaluation. Yet, 1 in 3 girls die from CVD and 1 in 10 girls undergo from endometriosis. Our outcomes counsel that it might be time to routinely think about the chance of CVD in girls with endometriosis,” mentioned lead research creator, Dr. Eva Havers-Borgersen from Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.

The research used Danish nationwide registries of all girls with a prognosis of endometriosis between 1977 and 2021. They had been matched with girls from the background inhabitants with out endometriosis in a 1:4 ratio based mostly on yr of delivery. The major final result was a composite of acute myocardial infarction and ischemic stroke. The secondary outcomes had been the person parts of the first final result, in addition to arrhythmias, coronary heart failure and mortality.

There had been 60,508 girls with endometriosis and 242,032 matched controls included within the evaluation (median age, 37.3 years) who had been adopted for a median of 16 years and a most of 45 years.

Women with endometriosis had round a 20% elevated threat of the composite endpoint of acute myocardial infarction and ischemic stroke in contrast with these with out endometriosis (unadjusted hazard ratio [HR] 1.18; 95% confidence interval [CI] 1.14−1.23; adjusted HR 1.15; 95% CI 1.11−1.20). The 40-year cumulative incidence of the composite of acute myocardial infarction and ischemic stroke was 17.5% (95% CI 16.6−18.2%) and 15.3% (95% CI 15.0−15.7%) in girls with and with out endometriosis, respectively (p<0.0001).

When this was damaged all the way down to the person parts, girls with endometriosis had round a 20% elevated threat of ischemic stroke (adjusted HR 1.18; 95% CI 1.12−1.23) and round 35% elevated threat of acute myocardial infarction (adjusted HR 1.35; 95% CI 1.31−1.40) in contrast with these with out endometriosis. Moreover, girls with endometriosis additionally had elevated threat of arrhythmias (adjusted HR 1.21; 95% CI 1.17−1.25) and coronary heart failure (adjusted HR 1.11; 95% CI 1.05−1.18) in contrast with these with out endometriosis.

Growing proof suggests there’s a shut relationship between endometriosis and the cardiovascular system and that they could share widespread illness pathways. Dr. Havers-Borgersen concluded, “Although absolutely the variations had been small, the relative variations had been 20%, and with the excessive prevalence of endometriosis, these outcomes present extra proof that female-specific threat components and CVD in girls want better consideration.

“We counsel that girls with endometriosis bear CVD threat evaluation, and it’s now time for female-specific threat components—reminiscent of endometriosis, but additionally gestational diabetes and pre-eclampsia—to be thought-about in cardiovascular threat prediction fashions. Further analysis is required to verify our findings and combine these components into efficient threat prediction fashions.”