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In a latest examine printed in Science China Life Sciences, it has been demonstrated that MSC-mediated mitochondrial switch can successfully restore mitochondrial DNA (mtDNA) and enhance mitochondrial operate in neural progenitor cells derived from sufferers with Leber’s hereditary optic neuropathy (LHON).
LHON is a genetic dysfunction that results in imaginative and prescient loss and blindness, primarily attributable to mutations in mtDNA that impair the operate of the respiratory chain.
The analysis workforce reprogrammed urine cells from LHON sufferers into induced pluripotent stem cells (iPSCs) and subsequently differentiated them into neural progenitor cells. By co-culturing these neural progenitor cells with MSCs, the examine noticed vital enhancements in mitochondrial operate and a rise within the proportion of regular mtDNA.
The outcomes recommend that MSCs can switch purposeful mitochondria to neural progenitor cells, thus restoring their operate and doubtlessly providing a brand new therapeutic technique for mitochondrial ailments. This examine gives a promising avenue for future analysis and scientific purposes in treating mitochondrial issues.
More data:
Rui Wang et al, MSC-mediated mitochondrial switch restores mitochondrial DNA and performance in neural progenitor cells of Leber’s hereditary optic neuropathy, Science China Life Sciences (2024). DOI: 10.1007/s11427-024-2647-8
Science China Press
Citation:
MSC-mediated mitochondrial switch holds therapeutic promise for Leber’s hereditary optic neuropathy sufferers (2024, August 29)
retrieved 29 August 2024
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